![]() Biochim Biophys Acta Bioenerg 1859:951–957. J Cell Sci 129:2297–2306īan T, Kohno H, Ishihara T, Ishihara N (2018) Relationship between OPA1 and cardiolipin in mitochondrial inner-membrane fusion. MacVicar T, Langer T (2016) OPA1 processing in cell death and disease - the long and short of it. Mishra P, Carelli V, Manfredi G, Chan DC (2014) Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation. Head B, Griparic L, Amiri M et al (2009) Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells. Iwasawa R, Mahul-Mellier A-L, Datler C et al (2011) Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction. Yu R, Jin S, Lendahl U et al (2019) Human Fis1 regulates mitochondrial dynamics through inhibition of the fusion machinery. Shen Q, Yamano K, Head BP et al (2014) Mutations in Fis1 disrupt orderly disposal of defective mitochondria. Mozdy AD, McCaffery JM, Shaw JM (2000) Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. Liu R, Chan DC (2015) The mitochondrial fssion receptor Mff selectively recruits oligomerized Drp1. Pagliuso A, Cossart P, Stavru F (2018) The ever-growing complexity of the mitochondrial fission machinery. Schrepfer E, Scorrano L (2016) Mitofusins, from Mitochondria to Metabolism. Green DE (1951) The cyclophorase complex of enzymes. Nature 171:30–31Įrnster L, Schatz G (1981) Mitochondria: a historical review. Sjostrand FS (1953) Electron microscopy of mitochondria and cytoplasmic double membranes. Palade GE (1953) An electron microscope study of the mitochondrial structure. Zhang H, Menzies KJ, Auwerx J (2018) The role of mitochondria in stem cell fate and aging. Wang C, Youle RJ (2009) The role of mitochondria in apoptosis*. Murphy MP (2009) How mitochondria produce reactive oxygen species. ĭuchen MR (2000) Mitochondria and calcium: from cell signalling to cell death. Lee JH, Park A, Oh KJ et al (2019) The role of adipose tissue mitochondria: regulation of mitochondrial function for the treatment of metabolic diseases. All rights reserved.Kühlbrandt W (2015) Structure and function of mitochondrial membrane protein complexes. ![]() We suggest that deeper understanding of the regulatory mechanisms within this system and downstream implications could benefit in understanding and intervention of these conditions.Īge-related disease Aging Fission Fusion Mitochondrial dynamics.Ĭopyright © 2020 The Author(s). Finally, we discuss the current evidence implicating these processes in age-related human pathologies, such as neurodegenerative or cardio-metabolic diseases. Here, we discuss the mechanisms of mitochondrial fission and fusion, the current evidence of their role in aging of multicellular organisms, and how these connect to cell cycle regulation, quality control, and transmission of energy status. There does exist, however, a large body of evidence connecting mitochondrial dynamics to other aging-related cellular processes and implicates them in a number of human diseases. While many mitochondrial processes are already characterized in relation to aging, specific evidence in multicellular organisms causally linking mitochondrial dynamics to the regulation of lifespan is limited. Mitochondria separate and merge using fission and fusion processes in response to changes in energy and stress status. Crucial to mitochondrial regulation is the dynamic nature of their network structure. Dysregulation of mitochondrial function is one of the classical hallmarks of aging, and mitochondrial interventions have repeatedly been shown to improve outcomes in age-related diseases. The mitochondria is the major hub to convert energy for cellular processes. ![]()
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